The Promise of Enhancer-Associated Long Noncoding Rnas in Cardiac Regeneration

Heart failure is a worldwide epidemic, and represents a major cause of morbidity and mortality. Current clinical therapies for heart disease prolong survival by protecting the viable muscle but are unable to replenish lost cardiomyocytes to restore function. Over the last decade, the notion of promoting cardiac regeneration has engendered considerable research interest. New strategies envisage the transfer of stem cells into the damaged myocardium, the mobilization of cardiac precursor cells or the promotion of cardiomyocyte proliferation in situ and direct reprogramming of non-cardiac cells into electromechanically coupled cardiomyocytes.
Source: Trends in Cardiovascular Medicine - Category: Cardiology Authors: Source Type: research