Immediate Effects of Sensorimotor Training in Airway Protection (smTAP) on Cough Outcomes in Progressive Supranuclear Palsy: A Feasibility Study

AbstractProgressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by a high prevalence of dysphagia, cough dysfunction, and resultant aspiration pneumonia. Sensorimotor cough function is important for airway clearance in people with dysphagia. Upregulation of cough has been demonstrated in healthy adults and Parkinson ’s disease; however, the feasibility of cough rehabilitation in PSP is unknown. We sought to assess feasibility by examining the immediate effects of a novel sensorimotor training in airway protection (smTAP) on upregulation of cough function in PSP. Fifteen individuals with PSP enrolled in this s tudy. Baseline voluntary and reflex cough testing were completed. During smTAP, participants were presented with subthreshold capsaicin and instructed to cough with sufficient intensity to hit a target line (set 25% above baseline reflex peak cough flow) via cough airflow visual biofeedback. Twenty- five repetitions were targeted within a single session. Wilcoxon signed-rank tests compared cough airflow measures between baseline voluntary cough testing, the initial five trials of smTAP, and final five trials. Mean peak expiratory flow rate (PEFR) significantly increased from initial to final sm TAP trials (p 
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research

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Countries around the world are making preparations against omicron, a new variant of the novel coronavirus that causes COVID-19. Although it hasn ’t yet been detected in the United States (as of Nov. 29, 2021), health officials are once again cautioning the public about getting vaccinated, frequent testing and potentially stepping up tried-and-true measures to prevent transmission such as mask-wearing and hand-washing.We spoke with  Shangxin Yang, a pathologist at UCLA Health, about the new variant and what everyone needs to know.How is the omicron variant different from the delta variant and others?It has ...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
ConclusionThis study shows the efficacy of 3D-ResNet as a rapid auxiliary diagnostic tool for NTB-LD and MTB-LD. Its use can help provide timely and accurate treatment strategies to patients with these diseases.
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
BACKGROUND: Freezing of gait (FOG) is a walking disturbance in advanced stage Parkinson's disease (PD) that has been associated with increased fall risk and decreased quality of life. Freezing episodes can be mitigated or prevented with external interventi...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Conditions:   COVID-19 Pneumonia;   COVID-19 Acute Respiratory Distress Syndrome Intervention:   Other: HFNO and NIV Sponsor:   Medipol University Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Heart rate variability is an increasingly popular measure of cardiovascular health. Heart rate variability is known to decline with age, but to what degree is this a reflection of processes of cardiovascular aging versus the loss of physical fitness that is a feature of old age in our present, overly sedentary societies? This remains an open question, and an important one, given the range of evidence for exercise programs, and thus increased physical fitness, to be as effective as many medical interventions when it comes to improving cardiovascular health and reducing mortality in later life. Yes, aging causes an inevitabl...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Kardiol Pol. 2021;79(11):1197-1205. doi: 10.33963/KP.a2021.0154.ABSTRACTCOVID-19 is a viral respiratory illness caused by the SARS-CoV-2 infection. In addition to lung disease, clinical complications of COVID-19 include myocardial damage and ischemia-related vascular disease. Severe manifestations and poor prognosis in these patients are associated with a hypercoagulable state predisposing to thrombotic-related complications and eventually death. However, these clinical features can also occur in other forms of pneumonia, such as community-acquired pneumonia (CAP), which, is also complicated by vascular diseases and charac...
Source: Kardiologia Polska - Category: Cardiology Authors: Source Type: research
CONCLUSION: Serotonin liberation from murine hippocampal sections is unaffected by acetylcholine. It is postulated that the bladder micturition reflex responds to acetylcholine through its immediate cholinergic activity rather than by its influence on serotonin release. These pathways are a promising target for the design of de novo therapeutic agents.PMID:34844394 | DOI:10.5213/inj.2142350.175
Source: International Neurourology Journal - Category: Urology & Nephrology Authors: Source Type: research
CONCLUSION: In PD-induced mice, resistance exercise enhanced AMPK phosphorylation to increase BDNF expression and new neuron generation, thereby improving spatial learning ability. Resistance exercise is believed to help improve symptoms of PD.PMID:34844387 | DOI:10.5213/inj.2142336.168
Source: International Neurourology Journal - Category: Urology & Nephrology Authors: Source Type: research
This study included 135 ptotic eyes of 103 patients who underwent blepharoptosis surgery. Facial photographs were taken preoperatively and postoperatively. Margin reflex distance (MRD) 1 and 2 of the operated eyes were manually measured by a senior surgeon. Multiple eyelid morphological parameters, such as MRD1, MRD2, upper eyelid length and corneal area, were automatically measured by our deep learning-based image analysis. Agreement between manual and automated measurements, as well as two repeated automated measurements of MRDs were analysed. Preoperative and postoperative eyelid morphological parameters were compared. ...
Source: Annals of Medicine - Category: Internal Medicine Authors: Source Type: research
A 34-year-old male presented to the emergency department with a penetrating injury of the left globe and orbit from a Thomas A Swift ’s Electric Rifle (TASER®) probe. The severity of the globe injury precluded primary closure of the globe; a primary evisceration was performed. In this article, we discuss not only the case in detail but also the TASER® rifle and the literature to support our decision in performing an evisceration rather than an enucleation, which historically has been taught to decrease the risk of sympathetic ophthalmia (SO) in the fellow eye. We are of the opinion, after reviewing the litera...
Source: Case Reports in Ophthalmology - Category: Opthalmology Source Type: research
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