Cardiovascular fingolimod effects on rapid baroreceptor unloading are counterbalanced by baroreflex resetting

ConclusionsVR-decreases 3 –6 hours after fingolimod initiation are physiologic results of fingolimod-associated attenuations of BP and HR increases at the end of strain and do not suggest impaired cardiovagal activation upon baroreceptor loading. Stable and at the time of HR nadir significantly increased BRGs indicate imp roved responses to baroreceptor unloading. Thus, cardiovascular fingolimod effects do not impair autonomic responses to sudden baroreceptor loading or unloading but seem to be mitigated by baroreflex resetting.
Source: Neurological Sciences - Category: Neurology Source Type: research