Targeting Peroxisome Proliferator-Activated Receptor- α (PPAR- α) to Reduce Paclitaxel-Induced Peripheral Neuropathy.

CONCLUSIONS AND IMPLICATIONS: Taken together, our results show for the first time the therapeutic potential (prevention and reversal) of fibrates in PIPN and opens to a potential pharmacological repurposing of these drugs.
PMID: 33434562 [PubMed - as supplied by publisher]

Source: Brain, Behavior, and Immunity - January 9, 2021 Category: Neurology Authors: Caillaud M, Patel NH, White A, Wood M, Contreras KM, Toma W, Alkhlaif Y, Roberts JL, Tran TH, Jackson AB, Poklis J, Gewirtz DA, Imad Damaj M Tags: Brain Behav Immun Source Type: research