L-bupivacaine Inhibition of Nociceptive Transmission in Rat Peripheral and Dorsal Horn Neurons

ConclusionsThese results suggest that the L-enantiomer of bupivacaine (L-bupivacaine) effectively inhibits noxious transmission to the spinal dorsal horn by blocking action potential conduction through C and A δ afferent fibers.Editor ’s PerspectiveWhat We Already Know about This TopicBoth the therapeutic and toxic effects of local anesthetics are influenced by the stereochemistry of these drugsL-bupivacaine has a favorable toxicity profile compared with D-bupivacaine, but possible differential effects on action potential conduction are poorly understoodWhat This Article Tells Us That Is NewThe concentration of L-bupivacaine required to block C and A δ neurons was lower than the required concentration of D-bupivacaineIn the spinal cord dorsal horn, L-bupivacaine appeared to be more selective for blocking nociceptive signal transmission than did D-bupivacaine
Source: Anesthesiology - Category: Anesthesiology Source Type: research