Molecules, Vol. 25, Pages 4926: Attenuation of Nrf2/Keap1/ARE in Alzheimer ’s Disease by Plant Secondary Metabolites: A Mechanistic Review

Molecules, Vol. 25, Pages 4926: Attenuation of Nrf2/Keap1/ARE in Alzheimer’s Disease by Plant Secondary Metabolites: A Mechanistic Review Molecules doi: 10.3390/molecules25214926 Authors: Sajad Fakhri Mirko Pesce Antonia Patruno Seyed Zachariah Moradi Amin Iranpanah Mohammad Hosein Farzaei Eduardo Sobarzo-Sánchez Alzheimer’s disease (AD) is a progressive neuronal/cognitional dysfunction, leading to disability and death. Despite advances in revealing the pathophysiological mechanisms behind AD, no effective treatment has yet been provided. It urges the need for finding novel multi-target agents in combating the complex dysregulated mechanisms in AD. Amongst the dysregulated pathophysiological pathways in AD, oxidative stress seems to play a critical role in the pathogenesis progression of AD, with a dominant role of nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein-1 (Keap1)/antioxidant responsive elements (ARE) pathway. In the present study, a comprehensive review was conducted using the existing electronic databases, including PubMed, Medline, Web of Science, and Scopus, as well as related articles in the field. Nrf2/Keap1/ARE has shown to be the upstream orchestrate of oxidative pathways, which also ameliorates various inflammatory and apoptotic pathways. So, developing multi-target agents with higher efficacy and lower side effects could pave the road in the prevention/management of AD. The plant kingd...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research