Effect of germline mutations in homologous recombination repair genes on overall survival of patients with pancreatic adenocarcinoma.

CONCLUSIONS: This study demonstrates that germline mutation carrier status in PDAC is associated with longer OS compared to non-carriers. Further research into tumor biology and response to platinum-based chemotherapy in germline mutation carriers with PDAC are needed to better understand the association with longer OS.
PMID: 33028596 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - October 7, 2020 Category: Cancer & Oncology Authors: Yadav S, Kasi PM, Bamlet WR, Ho TP, Polley EC, Hu C, Hart SN, Rabe KG, Boddicker NJ, Gnanaolivu RD, Lee KY, Lindstrom T, Petersen GM, Couch FJ, McWilliams RR Tags: Clin Cancer Res Source Type: research