Pilot Study: Texture analysis of PET imaging demonstrates changes in 18F-FDG uptake of the brain after prophylactic cranial irradiation.

Conclusion: Global changes in brain glucose metabolism occur after PCI and are detectable using advanced image processing techniques. These changes may reflect radiation-induced damage and thus may provide a novel method for studying radiation-induced cognitive impairment. PMID: 33020232 [PubMed - as supplied by publisher]
Source: Journal of Nuclear Medicine Technology - Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research

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Black pigmentation of the airways (black bronchoscopy) can be caused by many etiologies. We herein reported a case of black bronchoscopy for pulmonary malignant melanoma. A 47 ‐year‐old Japanese man was referred to our hospital with a one‐week history of chest discomfort. Chest computed tomography (CT) revealed a mass in the right upper lobe suspected to be primary lung cancer. A biopsy of the mass using endobronchial ultrasonography (EBUS) with guide sheath (GS) wa s performed, and a black‐colored mass was observed which occluded almost all of the right B2b bronchus. Immunohistochemistry of lung specimens was comp...
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: IMAGING IN THORACIC CANCER Source Type: research
EML4-ALK fusions are targetable oncogenic drivers in a subset of advanced non-small cell lung cancer (NSCLC) patients that can benefit from selected ALK inhibitors. Precise detection of ALK fusions may yield critical information for selection of appropriate therapy and hence improve patient survival. Analysis of circulating tumor DNA (ctDNA) in liquid biopsies using next generation sequencing (NGS) prior to or during treatment hold great promise for disease monitoring and treatment guidance of various cancers including NSCLC. Herein, we report a case of a 21-year-old advanced lung adenocarcinoma patient with a low abundanc...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: Anti-GABA-B receptor encephalitis mainly occurred in middle-aged and elderly men, and the disease onset was relatively sudden. Before disease onset, some patients experienced fever and non-specific respiratory symptoms, which mainly manifested as frequent epileptic seizures, cognitive dysfunction, and abnormal mental behavior. MRI and PET-CT revealed abnormal signals and local metabolism, respectively, in the temporal lobe. Moreover, the disease has a close relationship with lung cancer, which requires long-term follow-up observation.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusions: Based on the findings in this study, we suggest that FDG PET/MRI might be an effective cancer screening modality, especially in combination with lung CT. Table 1.The cancer type distribution of the subjectsNumber of casesorganShanghaiHangzhouTotalLung461561Thyroid527Breast415Digestive system (Stomach, Colon)4(1,3)1(1,0)5Urogenital system (Kidney, Prostate, Cervical)7(2,4,1)1(0,1,0)8Nasopharynx213Tonsil101Total692190Table 2. False positive cases detected by PET/MROrganShanghaiHangzhouTotalThyroid10616Colon112Stomach101Breast202Total14721Table 3.False negative cases missed by PET/MRNO.CenterAgeSexOrganHistologic...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Miscellaneous Source Type: research
This study is a multicenter, prospective, single ‐arm, phase II clinical study, and explores the efficacy and tolerability of SRS with anlotinib in NSCLC patients with limited brain metastases. The aim of the study is to provide new treatment options for NSCLC patients with brain metastases.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: STUDY PROTOCOL Source Type: research
Abstract PURPOSE: To provide evidence-based recommendations to practicing clinicians on radiographic imaging and biomarker surveillance strategies after definitive curative-intent therapy in patients with stage I-III non-small-cell lung cancer (NSCLC) and SCLC. METHODS: ASCO convened an Expert Panel of medical oncology, thoracic surgery, radiation oncology, pulmonary, radiology, primary care, and advocacy experts to conduct a literature search, which included systematic reviews, meta-analyses, randomized controlled trials, and prospective and retrospective comparative observational studies published from 2000...
Source: Ann Oncol - Category: Cancer & Oncology Authors: Tags: J Clin Oncol Source Type: research
Authors: Gulak MA, Bornais C, Shin S, Murphy L, Smylie J, Pantarotto JR, Fung-Kee-Fung M, Maziak DE Abstract Background: Patients with lung cancer often experience stressful delays throughout the diagnostic phase of care. To address that situation, our multidisciplinary team created a "Navigation Day," during which patients partake in a single-day visit that comprises nurse-led teaching, social work, smoking cessation counselling, symptom control, and dedicated test slots for integrated positron-emission tomography and computed tomography (pet/ct), pulmonary function tests (pfts), and magnetic resonance i...
Source: Current Oncology - Category: Cancer & Oncology Tags: Curr Oncol Source Type: research
Patients with non-small cell lung cancer (NSCLC) frequently develop brain metastases (BM) [1]. In patients with stage III NSCLC staged with a magnetic resonance imaging (MRI) or computed tomography (CT) scan of the brain, the incidence of BM is currently around 30%, and prognosis is typically poor [1]. Once BM have occurred, patients are treated with the intention to maintain their health-related quality of life (HRQoL) during their remaining lifespan [2].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
Non –small-cell lung cancer (NSCLC) guidelines advise to screen stage III NSCLC patients for brain metastases (BMs), preferably by magnetic resonance imaging (MRI) or when contraindicated or not accessible a dedicated contrast enhanced–computed tomography (dCE-CT), which can be incorporated in the staging 18Fluodeoxoglucose–positron emission tomography (18FDG-PET-CE-CT). In daily practice, often a dCE-CT is performed instead of a MRI. The aim of the current study is to evaluate the additive value of MRI after dCE-CT, incorporated in the 18FDG-PET-CE-CT.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Original Research Source Type: research
Conclusions The recent, first randomized clinical trial demonstrated overall and progression free survival benefits after SBRT to oligometastatic disease which supports prior retrospective case series (6). The spine is a common site of metastatic bone disease, and as high quality data continue to mature, along with completion of additional randomized clinical trials, it is expected that utility of SBRT to the spine will increase in the future. Spine SBRT is unique due to the requirement of sharp dose falloff to prevent serious neurologic morbidity. With recent advances in radiotherapy planning, robotic patient positionin...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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