TBC1D15/RAB7-regulated mitochondria-lysosome interaction confers cardioprotection against acute myocardial infarction-induced cardiac injury

Conclusions: Our findings indicated a pivotal role of TBC1D15 in acute MI-induced cardiac anomalies through Fis1/RAB7 regulated mitochondria-lysosome contacts and subsequent lysosome-dependent mitophagy flux activation, which may provide a new target in the clinical treatment of acute MI.

Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Wenjun Yu, Shiqun Sun, Haixia Xu, Congye Li, Jun Ren, Yingmei Zhang Tags: Research Paper Source Type: research