Engineered biomimetic nanoparticle for dual targeting of the cancer stem-like cell population in sonic hedgehog medulloblastoma [Engineering]
The sonic hedgehog subtype of medulloblastoma (SHH MB) is associated with treatment failure and poor outcome. Current strategies utilizing whole brain radiation therapy result in deleterious off-target effects on the normal developing childhood brain. Most conventional chemotherapies remain limited by ineffective blood–brain barrier (BBB) penetrance. These challenges signify an unmet...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Jinhwan Kim, Abhinav Dey, Anshu Malhotra, Jingbo Liu, Song Ih Ahn, Yoshitaka J. Sei, Anna M. Kenney, Tobey J. MacDonald, YongTae Kim Tags: Biological Sciences Source Type: research
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