Proteomic Profiling Reveals Roles of Stress Response, Ca2+ Transient Dysregulation and Novel Signaling Pathways in Alcohol-Induced Cardiotoxicity.
CONCLUSIONS: The observed changes in protein expression highlight the involvement of oxidative stress and dysregulation of Ca2+ handling and contraction while also implicating potential novel targets in alcohol-induced cardiotoxicity. These findings facilitate further exploration of potential mechanisms, discovery of novel biomarkers, and development of targeted therapeutics against ethanol-induced cardiotoxicity.
PMID: 32981093 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Liu R, Sun F, Forghani P, Armand LC, Rampoldi A, Li D, Wu R, Xu C Tags: Alcohol Clin Exp Res Source Type: research
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