Proteomic Profiling Reveals Roles of Stress Response, Ca2+ Transient Dysregulation and Novel Signaling Pathways in Alcohol-Induced Cardiotoxicity.

CONCLUSIONS: The observed changes in protein expression highlight the involvement of oxidative stress and dysregulation of Ca2+ handling and contraction while also implicating potential novel targets in alcohol-induced cardiotoxicity. These findings facilitate further exploration of potential mechanisms, discovery of novel biomarkers, and development of targeted therapeutics against ethanol-induced cardiotoxicity. PMID: 32981093 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Tags: Alcohol Clin Exp Res Source Type: research