Antenatal Dexamethasone Exposure Impairs the High-Conductance Ca2+-Activated K+ Channels via Epigenetic Alteration at Gene Promoter in Male Offspring.

CONCLUSIONS: Our findings showed a profound and long-term impact of antenatal dexamethasone exposure on vascular BK via an altered epigenetic pattern from fetal stage to adulthood, advancing understanding of prolonged adverse effects and mechanisms of antenatal glucocorticoids exposure on vascular health in offspring.
PMID: 32967457 [PubMed - as supplied by publisher]

Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 23, 2020 Category: Cardiology Authors: Xu T, Zhao M, Li H, Zhou X, Liu B, Sun M, Xu Z, Gao Q Tags: Arterioscler Thromb Vasc Biol Source Type: research