Anticancer drugs and cardiovascular-related hospitalization in metastatic colorectal cancer: Insights from the AVOCETTE population-based study.

Anticancer drugs and cardiovascular-related hospitalization in metastatic colorectal cancer: Insights from the AVOCETTE population-based study. Am J Epidemiol. 2020 Sep 23;: Authors: Dolladille C, Launoy G, Bouvier V, Salem JE, Legallois D, Milliez P, Sassier M, Lobbedez T, Guittet L, Alexandre J Abstract We aimed to investigate the association between anticancer drugs and cardiovascular-related hospitalization (CVRH) in metastatic colorectal cancer (mCRC) patients. A cohort study was conducted using the French county Calvados registry of digestive tumors. Incident mCRC cases between 2008 and 2014 were included. The follow-up end date was December 2016. Data from the county hospital center pharmacy and medical information departments were matched with the registry data. A competing risk approach was used. Statistical tests were two-sided. A total of 1,116 mCRC patients were included; they were administered 12,374 rounds of treatment; fluorouracil, oxaliplatin, irinotecan and bevacizumab were most common. A total of 208 CVRH events occurred in 145 patients (13.0%). The International Cancer Survival Standards type 1 standardized incidence was 84.0 CVRH per 1,000 person-years (95% confidence interval: 72.6-95.5). Anticancer drugs were not associated with a higher incidence of CVRH. Men, elderly patients, patients with a prior history of CVRH and patients with a higher Charlson comorbidity index were associated with a higher incidence of...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research