Perinatal androgens organize sex differences in mast cells and attenuate anaphylaxis severity into adulthood [Immunology and Inflammation]
Mast cell (MC)-associated diseases, including allergy/anaphylaxis and neuroinflammatory pain disorders, exhibit a sex bias, with females at increase risk. While much attention has been directed toward adult sex hormones as drivers of sex differences, that female sex bias in MC-associated diseases is evident in prepubertal children, suggesting early-life origins of...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Emily Mackey, Kyan M. Thelen, Vedrana Bali, Mahsa Fardisi, Madalyn Trowbridge, Cynthia L. Jordan, Adam J. Moeser Tags: Biological Sciences Source Type: research
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