High-Resolution Dynamic 31P-MR Spectroscopic Imaging for Mapping Mitochondrial Function

Conclusions: A new model-based method is proposed to achieve high-resolution dynamic 31P-MRSI. The proposed method's ability to delineate metabolic heterogeneity was demonstrated in rat hindlimb. Significance: Abnormal mitochondrial metabolism is a key cellular dysfunction in many prevalent diseases such as diabetes and heart disease; however, current understanding of mitochondrial function is mostly gained from studies on isolated mitochondria under nonphysiological conditions. The proposed method has the potential to - pen new avenues of research by allowing in vivo and longitudinal studies of mitochondrial dysfunction in disease development and progression.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research