Potential of platinum-resensitization by Wnt signaling modulators as treatment approach for epithelial ovarian cancer.

CONCLUSION: According to the described effects on EOC biology, all three Wnt manipulators seem to have the potential to augment the impact of a platinum-based chemotherapy in EOC. This is promising as a dominance of this pathway was confirmed in serous histology.
PMID: 32681294 [PubMed - indexed for MEDLINE]

Source: Clin Med Res - September 17, 2020 Category: Research Authors: Kaltofen T, Preinfalk V, Schwertler S, Fraungruber P, Heidegger H, Vilsmaier T, Vattai A, Czogalla B, Mayr D, Mahner S, Jeschke U, Trillsch F Tags: J Cancer Res Clin Oncol Source Type: research