Carbohydrate and fat intake associated with risk of metabolic diseases through epigenetics of CPT1A.

CONCLUSIONS: Our results suggest that the proportion of total energy supplied by CHO and FAT can have a causal effect on the risk of metabolic diseases via the epigenetic status of CPT1A.Study registration at https://www.clinicaltrials.gov/: the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN)-NCT01023750; and the Framingham Heart Study (FHS)-NCT00005121.
PMID: 32930325 [PubMed - as supplied by publisher]

Source: The American Journal of Clinical Nutrition - September 14, 2020 Category: Nutrition Authors: Lai CQ, Parnell LD, Smith CE, Guo T, Sayols-Baixeras S, Aslibekyan S, Tiwari HK, Irvin MR, Bender C, Fei D, Hidalgo B, Hopkins PN, Absher DM, Province MA, Elosua R, Arnett DK, Ordovas JM Tags: Am J Clin Nutr Source Type: research