Oxalobacter formigenes reduce the risk of kidney stones in patients exposed to oral antibiotics: a case –control study

AbstractThis is the first prospective study to investigate the association between kidney stones, bone mineral density, serum testosterone, colon cancer andO. formigenes colonization. 40 kidney stone patients and 85 controls were enrolled.O. formigenes colonization was established. BMD was examined from T- and Z-scores using dual energy absorptiometry.O. formigenes was found in 28 of 40 cases and 80 of 85 controls. BMD was significantly reduced in patients (p  <  0.05). The evaluation revealed a significant association between loweredO. formigenes colonization and low testosterone. Urinary calcium and oxalates levels were greater in patient. Serum testosterone and urinary citrate concentrations was reduced in patients with a significant difference. Also an association betweenO. formigenes and colon cancer was noted. Absence ofO. formigenes might stand for a pathogenic factor in calcium oxalate stone, low bone mineral density, low testosterone levels and also colon cancer, when antibiotics are prescribed generously.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research