The Gut Microbiota and Associated Metabolites Are Altered in Sleep Disorder of Children With Autism Spectrum Disorders
BackgroundAutism spectrum disorder (ASD) is a type of neurodevelopmental disease that is frequently accompanied by sleep disorder. Herein, we investigated changes in the gut microbiota and its metabolites correlated with core symptoms and sleep problems in children with ASD.MethodsOne hundred and twenty children diagnosed with ASD based on Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria were enrolled in our study. The Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and Childhood Autism Rating Scale (CARS) were used to assess autism symptoms, and the Children Sleep Habits Questionnaire (CSHQ) was employed to evaluate sleep problems in children with ASD. The 120 children were divided into a sleep disorder group (n = 60) and a control group without sleep disorder (n = 60) according to the CSHQ answers. Illumina MiSeq analysis of 16S rRNA genes was used to compare differences in gut microbiota, and metabolomics analysis was employed to asses associated metabolites.ResultsSRS and CARS scores for the sleep disorder group were significantly higher than for the control group (p
MONDAY, Oct. 5, 2020 -- Developmental and behavioral functioning often associated with children diagnosed with autism spectrum disorder (ASD), such as sensory sensitivity, aggression, and sleep disorders, may be linked to a nonverbal manifestation...
Abstract Fragile X syndrome (FXS), a neurodevelopmental disorder with autistic features, is caused by the loss of the fragile X mental retardation protein. Sex-specific differences in the clinical profile have been observed in FXS patients, but few studies have directly compared males and females in rodent models of FXS. To address this, we performed electroencephalography (EEG) recordings and a battery of autism-related behavioral tasks on juvenile and young adult Fmr1 knockout (KO) rats. EEG analysis demonstrated that compared to wild-type, male Fmr1 KO rats showed an increase in gamma frequency band power in th...
CONCLUSION: Further are required for understanding the relationship between melatonin, circadian rhythm and ASD, which will not only shed light on the role of melatonin in the etiology of ASD, but may also guide to early intervention options. PMID: 32978956 [PubMed - in process]
ConclusionThis case report provides evidence that a lower than previously reported dose of a phytocannabinoid in the form of a cannabidiol-based extract may be capable of aiding in autism spectrum disorder-related behavioral symptoms, core social communication abilities, and comorbid anxiety, sleep difficulties, and weight control. Further research is needed to elucidate the clinical role and underlying biological mechanisms of action of cannabidiol-based extract in patients with autism spectrum disorder.
If you find yourself wondering if everything will go wrong in 2020, you are far from alone. This year has seen more than its share of heartache, and it isn’t over yet. Help may never arrive — how can you keep going? It’s challenging to stay strong when everything seems to be going wrong. While the tips below are no substitute for professional care, financial and other circumstances don’t always make seeking treatment an option. These 10 self-care practices may keep you from capsizing when the seas grow rocky. 1. Take a Deep Breath Many times, you grow anxious from future fears, not fr...
Conditions: Insomnia Chronic; Autism Spectrum Disorder Interventions: Behavioral: In-Person CBT for insomnia in children with autism; Behavioral: Remote CBT for insomnia in children with autism; Behavioral: Remote sleep hygiene and related education (SHARE) for insomnia in children with autism Sponsors: University of Missouri-Columbia; United States Department of Defense Not yet recruiting
Conditions: Autism; Autism Spectrum Disorder; Sleep Intervention: Behavioral: Behavioral treatment for sleep difficulties Sponsor: Soroka University Medical Center Not yet recruiting