Pig Kidney Xenotransplantation: Progress Towards Clinical Trials
Pig organ xenotransplantation offers a solution to the shortage of deceased human organs for transplantation. The pathobiological response to a pig xenograft is complex, involving antibody, complement, coagulation, inflammatory, and cellular responses. To overcome these barriers, genetic manipulation of the organ-source pigs has largely been directed to two major aims – (i) deletion of expression of the known carbohydrate xenoantigens against which humans have natural (preformed) antibodies, and (ii) transgenic expression of human protective proteins, e.g., complement- and coagulation-regulatory proteins.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: David K.C. Cooper, Hidetaka Hara, Hayato Iwase, Takayuki Yamamoto, Zheng-Yu Wang, Abhijit Jagdale, Mohamed H. Bikhet, Huy Q. Nguyen, Jeremy B. Foote, Wayne D. Paris, David Ayares, Vineeta Kumar, Douglas J. Anderson, Jayme E. Locke, Devin E. Eckhoff Tags: Review Source Type: research
More News: Carbohydrates | Cardiology | Clinical Trials | Genetics | Heart | Heart Transplant | Kidney Transplant | Kidney Transplantation | Lung Transplant | Transplant Surgery | Transplants | Urology & Nephrology