Molecules, Vol. 25, Pages 3642: Antimicrobial O-Alkyl Derivatives of Naringenin and Their Oximes Against Multidrug-Resistant Bacteria
Molecules, Vol. 25, Pages 3642: Antimicrobial O-Alkyl Derivatives of Naringenin and Their Oximes Against Multidrug-Resistant Bacteria
Molecules doi: 10.3390/molecules25163642
Authors:
Anna Duda-Madej
Joanna Kozłowska
Paweł Krzyżek
Mirosław Anioł
Alicja Seniuk
Katarzyna Jermakow
Ewa Dworniczek
New antimicrobial agents are needed to address infections caused by multidrug-resistant bacteria. Here, we are reporting novel O-alkyl derivatives of naringenin and their oximes, including novel compounds with a naringenin core and O-hexyl chains, showing activity against clinical strains of clarithromycin-resistant Helicobacter pylori, vancomycin-resistant Enterococcus faecalis, methicillin-resistant Staphylococcus aureus, and beta-lactam-resistant Acinetobacter baumannii and Klebsiella pneumoniae. The minimum inhibitory concentrations (MICs), which provide a quantitative measure of antimicrobial activity, were in the low microgram range for the selected compounds. Checkerboard assays for the most active compounds in combination with antibiotics revealed interactions that varied from synergistic to neutral.
Source: Molecules - Category: Chemistry Authors: Anna Duda-Madej Joanna Koz łowska Pawe ł Krzyżek Miros ław Anioł Alicja Seniuk Katarzyna Jermakow Ewa Dworniczek Tags: Article Source Type: research
More News: Acinetobacter | Biaxin | Chemistry | Clarithromycin | Enterococcus | Helicobacter Pylori | MRSA | Multidrug Resistance | Staphylococcus Aureus