Roche provides update on phase III studies of etrolizumab in people with moderately to severely active ulcerative colitis

Basel, 10 August 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced topline results from its phase III study programme evaluating the investigational medicine etrolizumab in people with moderately to severely active ulcerative colitis. Mixed results were seen in studies evaluating etrolizumab as an induction therapy, and both studies evaluating etrolizumab as a maintenance therapy failed to meet their primary endpoints, showing no significant difference in the proportion of people achieving remission with subcutaneous etrolizumab versus placebo. In the HIBISCUS I induction study, in people without prior anti-tumour necrosis factor (anti-TNF) treatment, etrolizumab met the primary endpoint. In contrast, the HIBISCUS II induction study, which also included people without prior anti-TNF treatment, did not meet its primary endpoint. In the HICKORY study, in people with prior anti-TNF treatment, etrolizumab met the primary endpoint at induction but not at maintenance. In the LAUREL maintenance study in people without prior anti-TNF treatment, etrolizumab failed to meet its primary endpoint. The safety profile of etrolizumab was consistent with previous studies and no major safety issues were identified in the four phase III clinical trials reported to date.“We are disappointed with these results, because we know that people with ulcerative colitis need new treatment options,” said Levi Garraway, M.D., Ph.D., Roche's Chief Medical Officer and Head of Global Produ...
Source: Roche Media News - Category: Pharmaceuticals Source Type: news

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CONCLUSION: In our sample, percentages of variation in PLR and PD were found to be directly representative of TBI patients’ fentanyl blood concentration. Considering information about blood drug concentration is generally not available at bedside, PLR could be used as a proxy to assess analgesia requirements before a nociceptive procedure in critically ill sedated TBI patients who are vulnerable to stress.
Source: Journal of Neuroscience Nursing - Category: Neuroscience Tags: Articles Source Type: research
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
People who experience debilitating back pain come to their doctors with one pressing question: Do I need back surgery? Often, they are surprised to hear me, a neurosurgeon, answer, “No.” In many cases, physical therapy, pain management, weight loss management, and physiatry can help people to delay – and in some cases avoid – backRead more …Expertise is the backbone of successful spine treatment originally appeared inKevinMD.com.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Neurosurgery Orthopedics Source Type: blogs
Weekly injection of this anti-obesity medication could lead to a weight loss of 37 lb (17 kg).
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Weight Loss Source Type: blogs
WEIGHT LOSS isn't always easy, but you will make it harder by following fad diets which set you up for failure. Here are three pieces of diet advice to avoid, and the rules you should follow instead.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
In conclusion, neurovascular imaging in Loeys Dietz syndrome type III patients revealed abnormalities such as aneurysm, tortuosity, coiling and kinking in the vast majority of patients, but clinical events were rare. Neurovascular screening and follow up is advised in all Loeys Dietz syndrome type III patients.PMID:35031499 | DOI:10.1016/j.ejmg.2022.104424
Source: European Journal of Medical Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
CONCLUSIONS: The free antegrade palmaris longus tendocutaneous venous flap enabled the repair of compound tissue defects of the dorsal digit, resulting in acceptable aesthetics, repaired tendon defects, and wound coverage. This surgical method is an option for the reconstruction of small compound defects of digits with extensor defects.TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.PMID:35031123 | DOI:10.1016/j.jhsa.2021.11.023
Source: Hand Surgery - Category: Surgery Authors: Source Type: research
Int J Biol Macromol. 2022 Jan 11:S0141-8130(22)00010-1. doi: 10.1016/j.ijbiomac.2022.01.009. Online ahead of print.ABSTRACTSpherical cellulose nanocrystals (CNCs), as a new and high value cellulose derivative, shows excellent application potential in many fields due to its special structure. The accurate and effective separation of pure spherical CNCs lays foundation for its further application. In this work, spherical CNCs were prepared by enzymatic hydrolysis of microcrystalline cellulose (MCC) with complex enzymes. In order to determine the optimal separation conditions of pure spherical CNCs, turbidity and Zeta potenti...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Source Type: research
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Source: Pflugers Archiv : European Journal of Physiology - Category: Physiology Authors: Source Type: research
Queen Elizabeth II’s decision to strip Prince Andrew of his military titles and patronages was a brutal and humiliating exercise in damage-limitation, royal experts said. #elizabethii
Source: Reuters: Health - Category: Consumer Health News Source Type: news
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