Assessing and validating housekeeping genes in normal, cancerous, and polycystic human ovaries

ConclusionsThis study confirms recent investigations demonstrating that conventional HKGs, such as GAPDH and beta-actin, are not suitable reference genes for specific pathological conditions, emphasizing the importance of determining the best HKGs on a case-by-case basis and according to tissue type. Our results have identified reliable HKGs for studies of normal human ovaries and those affected by OEA, OMA, OSPC, or PCOS, as well as combined studies of control subjects vs. each cancer or PCOS group.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research