Cancers, Vol. 12, Pages 2072: Age Does Matter in Adolescents and Young Adults versus Older Adults with Advanced Melanoma; A National Cohort Study Comparing Tumor Characteristics, Treatment Pattern, Toxicity and Response
Cancers, Vol. 12, Pages 2072: Age Does Matter in Adolescents and Young Adults versus Older Adults with Advanced Melanoma; A National Cohort Study Comparing Tumor Characteristics, Treatment Pattern, Toxicity and Response
Cancers doi: 10.3390/cancers12082072
Authors:
Monique K. van der Kooij
Marjolein J.A.L. Wetzels
Maureen J.B. Aarts
Franchette W.P.J. van den Berkmortel
Christian U. Blank
Marye J. Boers-Sonderen
Miranda P. Dierselhuis
Jan Willem B. de Groot
Geke A.P. Hospers
Djura Piersma
Rozemarijn S. van Rijn
Karijn P.M. Suijkerbuijk
Albert J. ten Tije
Astrid A.M. van der Veldt
Gerard Vreugdenhil
Michel W.J.M. Wouters
John B.A.G. Haanen
Alfonsus J.M. van den Eertwegh
Esther Bastiaannet
Ellen Kapiteijn
Cutaneous melanoma is a common type of cancer in Adolescents and Young Adults (AYAs, 15–39 years of age). However, AYAs are underrepresented in clinical trials investigating new therapies and the outcomes from these therapies for AYAs are therefore unclear. Using prospectively collected nation-wide data from the Dutch Melanoma Treatment Registry (DMTR), we compared baseline characteristics, mutational profiles, treatment strategies, grade 3–4 adverse events (AEs), responses and outcomes in AYAs (n = 210) and older adults (n = 3775) who were diagnosed with advanced melanoma between July 2013 and July 2018. Compared to older adults, AYAs were more frequently female (51% versus 40%, p = 0.001), and had a be...
Source: Cancers - Category: Cancer & Oncology Authors: Monique K. van der Kooij Marjolein J.A.L. Wetzels Maureen J.B. Aarts Franchette W.P.J. van den Berkmortel Christian U. Blank Marye J. Boers-Sonderen Miranda P. Dierselhuis Jan Willem B. de Groot Geke A.P. Hospers Djura Piersma Rozemarijn S. van Rijn K Tags: Article Source Type: research
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