Cancers, Vol. 12, Pages 2072: Age Does Matter in Adolescents and Young Adults versus Older Adults with Advanced Melanoma; A National Cohort Study Comparing Tumor Characteristics, Treatment Pattern, Toxicity and Response

Cancers, Vol. 12, Pages 2072: Age Does Matter in Adolescents and Young Adults versus Older Adults with Advanced Melanoma; A National Cohort Study Comparing Tumor Characteristics, Treatment Pattern, Toxicity and Response Cancers doi: 10.3390/cancers12082072 Authors: Monique K. van der Kooij Marjolein J.A.L. Wetzels Maureen J.B. Aarts Franchette W.P.J. van den Berkmortel Christian U. Blank Marye J. Boers-Sonderen Miranda P. Dierselhuis Jan Willem B. de Groot Geke A.P. Hospers Djura Piersma Rozemarijn S. van Rijn Karijn P.M. Suijkerbuijk Albert J. ten Tije Astrid A.M. van der Veldt Gerard Vreugdenhil Michel W.J.M. Wouters John B.A.G. Haanen Alfonsus J.M. van den Eertwegh Esther Bastiaannet Ellen Kapiteijn Cutaneous melanoma is a common type of cancer in Adolescents and Young Adults (AYAs, 15–39 years of age). However, AYAs are underrepresented in clinical trials investigating new therapies and the outcomes from these therapies for AYAs are therefore unclear. Using prospectively collected nation-wide data from the Dutch Melanoma Treatment Registry (DMTR), we compared baseline characteristics, mutational profiles, treatment strategies, grade 3–4 adverse events (AEs), responses and outcomes in AYAs (n = 210) and older adults (n = 3775) who were diagnosed with advanced melanoma between July 2013 and July 2018. Compared to older adults, AYAs were more frequently female (51% versus 40%, p = 0.001), and had a be...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research