Constant-severe pain in chronic pancreatitis is associated with genetic loci for major depression in the NAPS2 cohort

ConclusionDepression is a major co-factor in the pain experience. This genetic predisposition to depression may have utility in counseling patients and in instituting early antidepressant therapy for pain management of pancreatitis patients. Prospective randomized trials are warranted.Clinical trials registrationClinicaltriasl.gov.# NCT01545167
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research