Zika virus induces oxidative stress and decreases antioxidant enzyme activities in vitro and in vivo.

Zika virus induces oxidative stress and decreases antioxidant enzyme activities in vitro and in vivo. Virus Res. 2020 Jul 02;:198084 Authors: Almeida LT, Ferraz AC, da Silva Caetano CC, da Silva Menegatto MB, Dos Santos Pereira Andrade AC, Lima RLS, Camini FC, Pereira SH, da Silva Pereira KY, de Mello Silva B, Perucci LO, Talvani A, de Magalhães JC, de Brito Magalhães CL Abstract The first outbreak of Zika virus (ZIKV) infection in the Americas, especially in Brazil, was reported in 2015. Fever, headache, rash, and conjunctivitis are the common symptoms of ZIKV infection. Unexpected clinical outcomes, such as microcephaly and Guillain-Barré syndrome, have also been reported. The recent spread of ZIKV and its association with severe illness has created an urgent need to understand its pathogenesis and find potential therapeutic targets. Studies show that some viruses, including Flavivirus, trigger oxidative stress, which affects cellular metabolism, viral cycle, and pathogenesis. However, the role of oxidative stress in ZIKV infection needs to be investigated. Here, we analyzed ZIKV infection-triggered oxidative stress and modified antioxidant enzyme activities. U87-MG and HepG2 cells were infected to measure reactive oxygen species (ROS), malondialdehyde (MDA), and carbonyl protein levels, the activities of superoxide dismutase (SOD) and catalase (CAT), and the activation of nuclear factor erythroid 2p45-related factor 2 (Nrf2). Z...
Source: Virus Research - Category: Virology Authors: Tags: Virus Res Source Type: research