Targeted alpha therapy in a systemic mouse model of prostate cancer - a feasibility study

Conclusion: C4-2 cells reproduced metastatic cancer spread most relevantly. Early treatment with 225Ac-PSMA-617 prevented liver metastases and led to significant survival benefit. Late treatment improved survival without reducing tumor burden in the liver, the main site of metastasis. The current findings suggest that early 225Ac-PSMA-617 intervention is more efficacious in the setting of widespread metastatic PCa.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Andreea D. Stuparu, Catherine A.L. Meyer, Susan L. Evans-Axelsson, Katharina L ü ckerath, Liu H. Wei, Woosuk Kim, Soumya Poddar, Christine E. Mona, Magnus Dahlbom, Mark D. Girgis, Caius G. Radu, Johannes Czernin, Roger Slavik Tags: Research Paper Source Type: research