Plant-Based Diets, the Gut Microbiota, and Trimethylamine N-Oxide Production in Chronic Kidney Disease: Therapeutic Potential and Methodological Considerations

High circulating trimethylamine-N-oxide (TMAO) is associated with an increased risk of cardiovascular disease and mortality in people with chronic kidney disease (CKD). In individuals with CKD, reduced kidney function leads to decreased excretion of TMAO, which results in accumulation in the circulation. Higher circulating TMAO has been linked to higher intake of animal-based foods in omnivorous diets. Thus, plant-based diets have been suggested as an intervention to slow the progression of CKD and reduce cardiovascular risk, perhaps explained in part by reduced TMAO production.

Source: Journal of Renal Nutrition - June 28, 2020 Category: Urology & Nephrology Authors: Gretchen N. Wiese, Annabel Biruete, Ranjani N. Moorthi, Sharon M. Moe, Stephen R. Lindemann, Kathleen M. Hill Gallant Tags: Review Article Source Type: research