Association of renin-angiotensin-aldosterone system genetic polymorphisms with maternal hypotension during spinal anaesthesia for caesarean delivery – a retrospective cohort study

Hypotension during spinal anaesthesia for caesarean delivery is a common problem, occurring in 70-80%1 of normotensive parturients. The clinical effects of severe intra-operative hypotension are not benign and range from maternal nausea, vomiting and headache to fetal acidosis, neurological injury and weak sucking reflexes.2,3 Spinal anaesthesia-induced hypotension results from blockade of thoracolumbar sympathetic outflow and decrease in systemic vascular resistance, with hypotension exacerbated by impaired venous return to the heart due to vena caval compression and venous pooling in the lower limbs.

Source: International Journal of Obstetric Anesthesia - June 26, 2020 Category: Anesthesiology Authors: H.S. Tan, Y.T. Gan, E.C. Tan, S. Nagarajan, R. Sultana, N-L R. Han, A.T.H. Sia, B.L. Sng Tags: Original Article Source Type: research