Insights into nanotherapeutic strategies as an impending approach for liver cancer treatment.

Insights into nanotherapeutic strategies as an impending approach for liver cancer treatment. Curr Top Med Chem. 2020 Jun 24;: Authors: Singh A, Shafi S, Upadhyay T, Najmi AK, Kohli K, Pottoo FH Abstract Liver cancer being the utmost prevalent fatal malignancy worldwide is ranked as fifth leading cause of deaths associated with cancer. Patients with liver cancer are diagnosed often at advanced stage, contributing to poor prognosis. Of all forms of liver cancer, hepatocellular carcinoma (HCC) contribute to 90% of cases, with chemotherapy being the treatment of choice. However, unfavorable toxicity of chemotherapy drugs and vulnerability of nucleic acid based drugs to degradation, have limited their application in clinical settings. So, in order to improvise their therapeutic efficacy in HCC treatment various nanocarrier drug delivery systems have been explored. Furthermore, nanoparticles (NPs) based imaging provide valuable means of accurately diagnosing HCC. Thus, in recent years, the advent of nanomedicine has shown great potential and progress in dramatically altering the approach to the diagnosis as well as treatment of liver cancer. NPs are been explored as potential drug carriers for small molecules, miRNAs, and therapeutic genes used for liver cancer treatment. This review emphasizes upon the current developments and applications of nanomedicine based therapeutic and diagnostic approaches in HCC. PMID: 32579503 [PubMed ...
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research