Impairment in neurocognitive function following experimental neonatal guinea pig cytomegalovirus infection.

CONCLUSION: Neonatal GPCMV infection in guinea pigs results in cognitive defects demonstrable by the MWM. This neonatal guinea pig challenge model can be exploited for studying antiviral interventions. IMPACT: CMV impairs neonatal neurocognition and memory in the setting of postnatal infection.The MWM can be used to examine memory and learning in a guinea pig model of neonatal CMV infection.CD4+ and CD8+ T cells infiltrate the brain following neonatal CMV challenge.This article demonstrates that the MWM can be used to evaluate memory and learning after neonatal GPCMV challenge.The guinea pig can be used to examine central nervous system pathology caused by neonatal CMV infection and this attribute may facilitate the study of vaccines and antivirals. PMID: 32555536 [PubMed - as supplied by publisher]
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research