Myelosuppressive and hepatotoxic potential of leflunomide and methotrexate combination in a rat model of rheumatoid arthritis.

CONCLUSIONS: In rats with AIA, current drug combinations provided higher therapeutic benefit compared to monotherapies, however, greater toxicities were observed. Therefore, continuous monitoring of hematologic parameters and liver function will be recommended in clinical settings.
PMID: 25560583 [PubMed - in process]

Source: Pharmacological Reports - January 11, 2015 Category: Drugs & Pharmacology Authors: Bilasy SE, Essawy SS, Mandour MF, Ali EA, Zaitone SA Tags: Pharmacol Rep Source Type: research