Fetal Cardiac Cellular Damage Caused by Anemia in Utero in Hb Bart's Disease.

CONCLUSION: Despite equivalent prenatal cardiac function and comparable cardiac iron accumulation in the Bart's and non-anemic groups, fetal anemia is significantly associated with cardiac mitochondrial dysfunction, increased mitochondrial fission, and increased inflammation and apoptosis. These findings indicate that an early phase of fetal anemia without cardiac iron overload can lead to cardiac mitochondrial dysfunction in fetuses with Hb Bart's.
PMID: 32520686 [PubMed - as supplied by publisher]

Source: Current Molecular Medicine - June 9, 2020 Category: Molecular Biology Authors: Jatavan P, Kumfu S, Tongsong T, Chattipakorn N Tags: Curr Mol Med Source Type: research