The NF- κB signalling pathway regulates GLUT6 expression in endometrial cancer.
CONCLUSIONS: TNFα is a cytokine that is commonly increased in obesity-related endometrial cancer and the findings herein support a potential mechanism whereby TNFα may contribute to endometrial cancer initiation or progression by increasing GLUT6 expression. Furthermore, we identified RELA, an important downstream mediator of the TNFα signalling cascade, as a regulator of GLUT6 expression in endometrial cells. Future studies are warranted to determine how GLUT6 expression affects endometrial tumourigenesis or cancer progression.
PMID: 32512041 [PubMed - as supplied by publisher]
Source: Cellular Signalling - Category: Cytology Authors: Caruana BT, Byrne FL Tags: Cell Signal Source Type: research
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