Progression of obsessive compulsive disorder-like grooming in Sapap3 knockout mice: A longitudinal [11C]ABP688 PET study.

CONCLUSION: Sapap3 ko mice show a decline in mGluR5 availability in OCD relevant brain regions parallel to the worsening of OCD-like behavior. This demonstrates a potential role for [11C]ABP688 PET as a biomarker to monitor disease progression in vivo.
PMID: 32454126 [PubMed - as supplied by publisher]

Source: Neuropharmacology - May 22, 2020 Category: Drugs & Pharmacology Authors: Glorie D, Verhaeghe J, Miranda A, Kertesz I, Wyffels L, Stroobants S, Staelens S Tags: Neuropharmacology Source Type: research