The inflammasome adaptor ASC delays UV-induced skin tumorigenesis in Beta HPV38 E6 and E7 Transgenic mice.

Non-melanoma skin cancer (NMSC) is the most common cancer in fair-skinned adults and comprises basal-cell carcinoma (BCC) and squamous-cell carcinoma (SCC). Its incidence reaches 1/100 person-year in Australia (Lomas et al. 2012), and is still on the rise worldwide (Madan et al. 2010). Development of NMSC depends on genetic and environmental factors. Particularly, there is clear evidence that cumulative sun exposure contributes to the development of NMSC (Ananthaswamy et al. 1997; Madan et al. 2010).

Source: Journal of Investigative Dermatology - May 24, 2020 Category: Dermatology Authors: Flora Magnotti, S éverine Valsesia, Purnima Gupta, Christa Flechtenmacher, Pierre Contard, Daniele Viarisio, Assunta Venuti, Mélanie Wencker, Massimo Tommasino, Jacqueline Marvel, Thomas Henry Tags: Letters to the Editor Source Type: research