Brown vs white adipose tissue roles of pericardial fat

This study was conducted using serum and adipose tissue samples collected from pericoronary depots in patients undergoing coronary artery bypass grafting and patients without coronary artery disease undergoing aortic valve replacement [3]. Adipokine synthesis pattern of epicardial also changes in obesity and dyslipidemia. Adiponectin synthesis comes down and proinflammatory adipokines like leptin, tumour necrosis factor alpha, interleukin 1 beta, interleukin 6 and resistin gets synthesised. These are proinflammatory, causing macrophage infiltration, destruction of microvasculature and increase in fibrosis [1]. In one study, abdominal and epicardial fat tissue samples were obtained from those with coronary artery disease undergoing coronary artery bypass grafting and from those without coronary artery disease undergoing other types of open heart surgery. Tissue levels of tumor necrosis factor-alpha, interleukin-6 and leptin were significantly higher in those with coronary artery disease [4]. Reference Packer M. Epicardial Adipose Tissue May Mediate Deleterious Effects of Obesity and Inflammation on the Myocardium. J Am Coll Cardiol. 2018 May 22;71(20):2360-2372. Fitzgibbons TP, Kogan S, Aouadi M, Hendricks GM, Straubhaar J, Czech MP. Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation. Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1425-37. Skrabal CA, Czaja J, Honz K, Emini R, Hannekum A, Friedl R. Adiponectin–...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology Source Type: blogs