DOHaD (Barker hypothesis): a disease-oriented, epoch-making theory of British origin with Hungarian roots.

[DOHaD (Barker hypothesis): a disease-oriented, epoch-making theory of British origin with Hungarian roots]. Orv Hetil. 2020 Apr 01;161(16):603-609 Authors: Csaba G Abstract The "developmental origin of health and disease" (DOHaD) theory emerged in 1986, demonstrating the statistical association of early developmental abnormalities (e.g., malnutrition or overeating, infant mortality) with adult non-communicable diseases (e.g., ischemic heart disease) by comparative epidemiological studies. , hypertension) - and has since become widespread. The theory is very similar to the concept of hormonal imprinting, which appeared 6 years earlier and demonstrated the role of perinatal encounter with hormone-like molecules in the occurrence of adult endocrine and endocrine-regulated pathological phenomena based on animal experiments. What is the same in both theories is the relationship between perinatal exposure and the adult phenomenon (disease) - this suggests a disorder in epigenetic programming. Barker was already familiar with hormonal imprinting when he developed the hugely important DOHaD theory, which he described as a possible cause of DOHaD, and this may have encouraged him in developing the theory. According to Barker, DOHaD applies to non-communicable diseases, but given that faulty hormonal imprinting also has a fundamental and lifelong effect on the immune system in adulthood, infectious diseases and even lifelong involvement are possible. Th...
Source: Orvosi Hetilap - Category: General Medicine Authors: Tags: Orv Hetil Source Type: research

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Source: Heart and Vessels - Category: Cardiology Source Type: research
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Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
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Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
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Source: American Journal of Hypertension - Category: Cardiology Authors: Tags: Am J Hypertens Source Type: research
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Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
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