Spermatogonial Stem Cell Culture in Oncofertility.
Spermatogonial Stem Cell Culture in Oncofertility.
Urol Clin North Am. 2020 May;47(2):227-244
Authors: David S, Orwig KE
Abstract
Infertility caused by chemotherapy or radiation treatments negatively impacts patient-survivor quality of life. The only fertility preservation option available to prepubertal boys who are not making sperm is cryopreservation of testicular tissues that contain spermatogonial stem cells (SSCs) with potential to produce sperm and/or restore fertility. SSC transplantation to regenerate spermatogenesis in infertile adult survivors of childhood cancers is a mature technology. However, the number of SSCs obtained in a biopsy of a prepubertal testis may be small. Therefore, methods to expand SSC numbers in culture before transplantation are needed. Here we review progress with human SSC culture.
PMID: 32272995 [PubMed - in process]
Source: The Urologic Clinics of North America - Category: Urology & Nephrology Authors: David S, Orwig KE Tags: Urol Clin North Am Source Type: research
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