How COVID has stalled potentially lifesaving research at OHSU
Research into cancer, heart disease, HIV, MS, Alzheimer ’s, gene therapy, opioid addiction, epilepsy, blindness — all abruptly stopped in mid-March.
Publication date: Available online 3 June 2020Source: Life SciencesAuthor(s): Milad Ashrafizadeh, Ali Zarrabi, Kiavash Hushmandi, Vahideh Zarrin, Ebrahim Rahmani Moghadam, Amirhossein Zabolian, Shima Tavakol, Saeed Samarghandian, Masoud Najafi
Publication date: Available online 3 June 2020Source: Life SciencesAuthor(s): Rohan Gupta, Rashmi K. Ambasta, Pravir Kumar
Publication date: 1 September 2020Source: Life Sciences, Volume 256Author(s): Neda Khalili, Masoud Nouri-Vaskeh, Zahra Hasanpour Segherlou, Amir Baghbanzadeh, Monireh Halimi, Haleh Rezaee, Behzad Baradaran
Publication date: Available online 2 June 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Ping Huang, Guanchun Wang, Zhaohong Wang, Cancan Zhang, Fengmian Wang, Xiaoxiao Cui, Sini Guo, Wei Huang, Rong Zhang, Deyue Yan
Publication date: 24 September 2020Source: Inorganica Chimica Acta, Volume 510Author(s): Thankaraj Salammal Sheena, Rajakumaran Dhivya, Venkatesan Rajiu, K. Jeganathan, Mallayan Palaniandavar, Ganesan Mathan, Mohammad Abdulkader Akbarsha
CONCLUSIONS: The introduction of spacer sequence between chelator and BBN(7-14) led to improved bidistribution. Analogue with tri-Gly spacer is the more promising radiopeptide for targeting GRP receptor than Ser conjugate. Therefore, these analogs can be considered as a candidate for the identification of bombesin-positive tumors. PMID: 32497000 [PubMed - as supplied by publisher]
Conclusion: This study concluded that the knowledge level of college students on Alzheimer's disease is below moderate. The findings concluded that there is association between faculty and knowledge score. PMID: 32494366 [PubMed]
Publication date: Available online 5 June 2020Source: Toxicology ReportsAuthor(s): Doha H. Abou Baker, Bassant M.M. Ibrahim, Nabila S. Hassan, A.F Yousuf, Souad El Gengaihi
Authors: Ao H, Li Y, Li H, Wang Y, Han M, Guo Y, Shi R, Yue F, Wang X Abstract Hydroxy genkwanin (HGK), a flavonoid compound from natural resources, showed good inhibition against the growth of breast tumor cells. However, the poor solubility restricted the further study and the in vivo drug delivery of HGK. We prepared HGK nanosuspensions by antisolvent precipitation method and investigated their characterization, stability, hemolysis probability, release behavior in vitro, antitumor activity in vitro and in vivo, and preliminary safety through acute toxicity experiments. The resultant HGK nano...
Authors: Zhang X, Ren X, Tang J, Wang J, Zhang X, He P, Yao C, Bian W, Sun L Abstract Multidrug resistance (MDR) of cancer cells is a significant challenge in chemotherapy, highlighting the urgent medical need for simple and reproducible strategies to reverse this process. Here, we report the development of an active tumor-targeting and redox-responsive nanoplatform (PA-ss-NP) using hyaluronic acid-g-cystamine dihydrochloride-poly-ε-(benzyloxycarbonyl)-L-lysine (HA-ss-PLLZ) to co-deliver paclitaxel (PTX) and apatinib (APA) for effective reversal of MDR. This smart nanoplatform specifically bound to CD44 rec...