Head and neck metachronous tumors - clinical, histopathological and immunohistochemical study.
Head and neck metachronous tumors - clinical, histopathological and immunohistochemical study. Rom J Morphol Embryol. 2019;60(4):1199-1206 Authors: Moţ IC, Poenaru M, Mogoantă CA, Istrate-Ofiţeru AM, Oprişcan IC, Sarău CA, Mănescu MD, Enăchescu V, Dogaru CA, Popescu C, Morar R, Balica NC, Horhat ID Abstract Multiple primary tumors (MPT) represent an important factor affecting the survival of some patients. They present an incidence of about 0.7-11% of all carcinomas developing in any region of the human body, being either synchronous or metachronous. These tumors raise problems of differential diagnosis, with tumoral relapses and distance metastases; also, they involve problems related to chemotherapy, radiotherapy and surgical treatment. In the present paper, we studied a group of 902 patients diagnosed with head and neck tumors admitted to the Ear, Nose &Throat (ENT) Clinic of the Emergency County Hospital of Timişoara, Romania, and we identified 12 patients with metachronous tumors, representing 1.33% of the hospitalized cases. Of the 12 patients with metachronous tumors, a single case was a woman, the other 11 cases being diagnosed in men. Regarding the age of the patients with metachronous tumors, only a single patient was aged less than 60 years old; most of them (nine patients) were aged between 60 and 69 years old, while two patients were aged over 70 years old. Nine patients were alcohol consumers, while 10 (83.33%) patients were smok...
Publication date: Available online 28 May 2020Source: Hepatobiliary &Pancreatic Diseases InternationalAuthor(s): Yue Yan, Yun-Hai Luo, Dao-Feng Zheng, Tong Mu, Zhong-Jun Wu
Publication date: Available online 27 May 2020Source: American Journal of OtolaryngologyAuthor(s): Theodwros-Leonidas Pantazis, Aris I. Giotakis, Sotirios Karamagkiolas, Ioannis Giotakis, Manousos Konstantoulakis, Aliki Liakea, Evangelos P. Misiakos
Publication date: Available online 27 May 2020Source: International Journal of PharmaceuticsAuthor(s): Rogério A. Santos, Mariana Rae, Vanessa F.M.C. Dartora, Jenyffer K.R. Matos, Rosana Camarini, Luciana B. Lopes
Authors: Bille A, Okiror L, Harling L, Pernazza F, Muzio A, Roveta A, Grosso F Abstract AIM: To report the outcomes and prognosis of patients with malignant pleural mesothelioma (MPM) who present with or develop metastases during treatment. METHODS: This is a retrospective observational study of patients diagnosed with MPM over 7 years. Metastases at presentation or during follow-up were recorded. Multivariate Cox regression was used to evaluate the relationship of clinicopathologic variables and overall survival (OS). Logistic regression was used for propensity score matching of patients to assess chemotherapy...
CONCLUSION: According to immunohistologic and biological findings in our patient both on primary tumor and liver metastasis, we hypothesize that selected patients with metastatic pRCC, progressed to standard/available treatments (including angiogenic drugs, mTOR inhibitors, and immunotherapy) and dissociated response to everolimus, could benefit from adding lenvatinib to everolimus. PMID: 32458743 [PubMed - as supplied by publisher]
CONCLUSION: The patterns of care and treatment outcomes were potentially consistent with world standards, needing future validation. This is the largest study of newly diagnosed nasopharyngeal cancer in Indonesia, a huge disease burden, providing an important basis for the clinical management of this disease. PMID: 32458659 [PubMed - in process]
Authors: Atef N, Alieldin N, Sherif G, Loay I, Mostafa Mahmoud A, Mohamed G Abstract BACKGROUND: Colorectal cancer (CRC) in Egypt is a relatively high young onset disease. As a form of heterogeneous cancer, there is interplay between genetic and environmental factors. We aimed at probing the association of life style factors and Microsatellite Instability (MSI) status that could provide more insights on carcinogenic process of CRC. METHODS: One hundred incident sporadic CRC patients were involved. Information on risk factors of CRC was obtained and microsatellite instability status was predicted through evaluat...
CONCLUSIONS: The study showed disparity in the expression of HER-2/neu in OSCC, which is due to multiple reasons. Therefore therapy against HER-2/neu in OSCC is debatable. PMID: 32458657 [PubMed - in process]
CONCLUSION: Our findings of overexpression of LAT1 in negative HER2 group suggest a role of this protein as prognosticator and drug target in a challenging therapeutic cohort.. PMID: 32458655 [PubMed - in process]
This study aimed to assess effects of the sets of EBV and HPV expressed proteins simultaneously on the sets of cellular/inflammatory factors in breast and thyroid cancers using structural equation modeling. In this multi-center case-control study, according to the inclusion and exclusion criteria, 83 breast and 57 thyroid specimens were collected from the eligible patients. In addition, 31 and 18 histopathological evaluated normal breast and thyroid samples were also examined as age-matched healthy controls. In addition, ELISA and Real-time PCR were used to measure the expression level of viral and cellular/inflammatory ge...
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