New-Onset Delusions Heralding an Underlying Neurodegenerative Condition: A Case Report and Review of the Literature.

CONCLUSIONS: Neurodegenerative disease should be on the differential diagnosis for any patient presenting with new-onset psychosis and behavioral changes in mid to late adulthood. Should red-flag features be present, early referral to a clinic specializing in dementia is recommended for further evaluation. This case highlights that MAPT mutations can be associated with psychosis in FTD and should be considered in the genetic workup. Ongoing research into the cellular and neural circuit mechanisms of psychosis in neurodegenerative disease may shed light on pathologic processes underlying psychosis in primary psychiatric disorders. PMID: 32237299 [PubMed - in process]
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

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DiscussionIf PROMs are helpful in improving patient outcomes for depression even to a small extent, then they are likely to be good value for money, given their low cost. The benefits could be considerable, given that depression is common, disabling, and costly.Trial registrationISRCTN no: 17299295. Registered 1st October 2018.
Source: Trials - Category: Research Source Type: clinical trials
Driving around her Kearney, Missouri neighborhood is both respite and torture for Kathie Hodgson. She likes seeing other people out and about; it reminds her what life was like before COVID-19. But Hodgson, a 41-year-old teacher who lives alone after a recent divorce, says seeing happy families playing in their yards or walking their dogs can also send her plunging deep into a spiral of loneliness. “You know, as much as I have valued my independence in the past year, it’s finally hitting me that I would like to curl up on the couch with somebody at night,” Hodgson says. The irony, Hodgson says, is she wa...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
Authors: Hossain MM, Purohit N, Sultana A, Ma P, McKyer ELJ, Ahmed HU Abstract Mental disorders are highly prevalent in eight South Asian countries, yet there is a gap of a synthesized overview of the prevalence of mental disorders in this region. This umbrella review aims to summarize the prevalence of mental disorders from systematic reviews and meta-analyses of South Asian studies. A systematic search of 11 major databases and additional sources was conducted until December 11, 2019. Articles were included if they were systematic reviews or meta-analyses, reported the prevalence of mental disorders, and reported...
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
AbstractPurpose of ReviewTo provide consultation –liaison psychiatrists with an updated resource that can assist in the treatment and management of geriatric patients.Recent FindingsThe current available literature has not shown any differences in efficacy between haloperidol and second-generation antipsychotics in patients with delirium. When considering relative advantages of forms of antipsychotic administration, there is no support for a superior safety profile of oral compared to intramuscular or intravenous administration. A recent meta-analysis of four randomized controlled trials concluded that when melatonin...
Source: Current Psychiatry Reports - Category: Psychiatry Source Type: research
This study aimed to investigate the occurrence of suicidal ideation and associated factors in older persons with dementia living at home in eight European countries, and its association with quality of life. Furthermore, changes in suicidal ideation over time were investigated.Methods: This cohort study (n = 1,223) was part of the European "RightTimePlaceCare" project conducted in 2010-2013. Participating countries were Estonia, Finland, France, Germany, the Netherlands, Spain, Sweden and the United Kingdom. Baseline and follow-up data were analysed using bivariate and multivariate logistic regressi...
Source: Aging and Mental Health - Category: Geriatrics Authors: Tags: Aging Ment Health Source Type: research
It is increasingly recognized that there is significant heterogeneity in phenotype and clinical trajectories in Alzheimer's disease as well as Lewy Body and Vascular dementia. Relatively common neurodegenerative disorder, Lewy Body Dementia (LBD) presents with psychiatric features. Mood disorders are common and often precede core symptoms of LBD. Patient with LBD especially early in the course of disease are at increased risk for suicide. Psychosis is one of the most debilitating symptoms of LBD as it is an independent risk factor for nursing home placements, increased caregiver distress and mortality.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Session 304 Source Type: research
On August 11th, 2014, news of actor Robin William's unexpected death echoed around the world. Three months after his passing, the coroner's report found that he had the little-known Dementia with Lewy Bodies (DLB). His death from suicide marked the end of an intense, confusing and relatively swift persecution at the hand of this disease's symptoms and pathology1. Adding to the confusion was the uncertainty, difficulty in diagnosing and caring for the constellation of his symptoms. Having previously suffered from depression, and with DLB bringing severe anxiety and psychosis, mental health care was a critical component of h...
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Invited Perspective Source Type: research
It is increasingly recognized that there is significant heterogeneity in phenotype and clinical trajectories in Alzheimer's disease as well as Lewy Body and Vascular dementia. Relatively common neurodegenerative disorder, Lewy Body Dementia (LBD) presents with psychiatric features. Mood disorders are common and often precede core symptoms of LBD. Patient with LBD especially early in the course of disease are at increased risk for suicide. Psychosis is one of the most debilitating symptoms of LBD as it is an independent risk factor for nursing home placements, increased caregiver distress and mortality.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: BRIDGING THE GAP BETWEEN NEUROLOGY AND PSYCHIATRY- PSYCHIATRIC SYMPTOMS IN THE COURSE OF NEURODEGENERATIVE DISORDERS Source Type: research
Depressed older adults are at high-risk for suicidal behavior (Pfeiffer et al., 2013, Vannoy et al., 2007) and for developing dementia (Kaup et al, 2016; Mizra et al., 2016). Executive dysfunction has been described across the life-span in suicide attempters (Keilp et al., 2013, Clark et al., 2011, Richards-Devantoy et al., 2012). However, few studies have explored the links between several domains of cognition and suicide risk in those with late-life depression and the extant evidence is equivocal at best (Conejero et al., 2018, Tu et al., 2018, Erlangsen et al., 2008).
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Poster Number: EI-61 Source Type: research
Should people with Alzheimer's be covered by California's assisted suicide law? One experience suggests no.
Source: L.A. Times - Health - Category: Consumer Health News Source Type: news
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