The change in prevalence of suspected non-alcoholic fatty liver disease in Korean adolescents from 2001 to 2017.

Conclusions: The prevalence of suspected NAFLD continues to increase in Korean adolescents.Abbreviations: ALT, alanine aminotransferase; BMI, body mass index; KNHANES, Korea National Health and Nutrition Examination Survey; NAFLD, non-alcoholic fatty liver disease. PMID: 32223545 [PubMed - as supplied by publisher]
Source: Paediatrics and international child health - Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research

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Background/AimsIncreasing evidence shows that non-alcoholic fatty liver disease (NAFLD) is associated with dysregulation of microvascular perfusion independently of established cardio-metabolic risk factors. We investigated whether hepatic manifestations of NAFLD such as liver fibrosis and liver fat are associated with microvascular hemodynamics through dysregulation of neurovascular control.MethodsMicrovascular dilator (post-occlusive reactive hyperemia) and sympathetically mediated constrictor (deep inspiratory breath-hold) responses were measured at the forearm and finger, respectively, using laser Doppler fluximetry. N...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Bariatric surgery has been shown to significantly improve both liver biochemistry and histology leading to improvements in Non Alcoholic Fatty Liver Disease (NAFLD). The Endobarrier is an endoscopically implanted duodenal jejunal bypass liner (DJBL) designed to mimic the effects of bariatric surgery leading to significant weight loss and improvements in glycaemic control. The purpose of this sub-study was to evaluate the effects of DJBL therapy on liver plasma parameters of NAFLD in obese patients with Type 2 Diabetes (T2DM).
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Poster abstracts Source Type: research
Diabetes mellitus is the 7th leading cause of death worldwide according to the World Health Organization. The rate of obesity has reached epidemic proportions in westernized countries. Non-alcoholic fatty liver disease (NAFLD) is associated with diabetes and obesity and is currently a leading etiology for liver transplantation in the United States. The duodenum plays an important role in nutrient absorption and glucose metabolism. Duodenal mucosal resurfacing (DMR) is a novel endoscopic technique of hydrothermal ablation of the duodenal mucosa potentially improving glycemic control.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Poster abstracts Source Type: research
AbstractPurpose of ReviewThis review summarizes recent animal and human trials examining the potential for kefir to improve obesity, type 2 diabetes, dyslipidemia, and non-alcoholic fatty liver disease (NAFLD). Evidence for pathways affected and suggestions of possible mechanisms of action are also considered.Recent FindingsHuman trials examining the ability of kefir to recapitulate metabolic health benefits previously observed in rodent models have found mixed results.SummaryKefir has long been associated with improvements in health including obesity, diabetes, NAFLD, and dyslipidemia in preventative animal trials. While ...
Source: Current Nutrition Reports - Category: Nutrition Source Type: research
We, previously, demonstrated that children with Down syndrome (DS) exhibited a greater risk of steatosis than the general pediatric population. This trend is independent of obese phenotype, thus suggesting a role of genetic predisposition. Therefore, we investigated the prevalence of non-alcoholic fatty liver disease and metabolic syndrome (MetS) in function of genetic susceptibility and adipocytokine levels in children with DS.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
Publication date: Available online 23 May 2020Source: Journal of EthnopharmacologyAuthor(s): Seong-hwan Park, Jung-Eun Lee, So Min Lee, Jueun Lee, Chang-Seob Seo, Geum-Sook Hwang, Jeeyoun Jung
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
In this study, we show that perforin can act as an immune regulator to prevent the progression of NAFLD. Aged perforin-deficient (Prf−/−) mice have increased lipid accumulation in the liver compared to WT mice. With high-fat diet (HFD) challenge, Prf−/− mice have increased liver weight, more severe liver damage, and increased liver inflammation when compared with WT controls. Mechanistic studies revealed that perforin specifically regulates intrinsic IFN-γ production in CD4 T cells, not CD8 T cells. We found that CD4 T cell depletion reduces liver injury and ameliorates the inflammation and me...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Abstract Volatile organic compounds (VOCs), such as vinyl chloride (VC), can be directly toxic at high concentrations. However, we have shown that 'nontoxic' exposures to VC and its metabolite chloroethanol (CE) enhances experimental non-alcoholic fatty liver disease (NAFLD), suggesting an unpredicted interaction. Importantly, VOC exposure has been identified as a potential risk factor for the development of obesity and its sequelae in humans. As there is a known axis between adipose and hepatic tissue in NAFLD, the impact of CE on white adipose tissue (WAT) inflammation and lipolysis was investigated. Mice were a...
Source: Toxicology and Applied Pharmacology - Category: Toxicology Authors: Tags: Toxicol Appl Pharmacol Source Type: research
In conclusion, LAGB-induced weight loss reduces hepatic TSK expression. Inhibiting TSK might represent a promising target for treating NAFLD in the future. PMID: 32442908 [PubMed - as supplied by publisher]
Source: Cytokine - Category: Molecular Biology Authors: Tags: Cytokine Source Type: research
;mez-Huelgas María Rosa Bernal-López The aim of this study was to analyze the utility of liver function tests (LFT) and fatty liver index (FLI), a surrogate marker of non-alcoholic fatty liver disease, in the categorization of metabolic phenotypes in a Mediterranean population. A cross-sectional study was performed on a random representative sample of 2233 adults assigned to a health center in Málaga, Spain. The metabolic phenotypes were determined based on body mass index (BMI) categorization and the presence or absence of two or more cardiometabolic abnormalities (high blood pressure, low h...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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