A Critical Review on Structural Neuroimaging Studies in BD: a Transdiagnostic Perspective from Psychosis to Fronto-Temporal Dementia

AbstractRecent FindingsIn the last decades, many neuroimaging studies have investigated the brain structural deficits associated with the pathophysiology of Bipolar Disorder (BD). Notably, the available literature identified the presence of selective brain structural abnormalities, in terms of both gray matter (GM) and white matter, known to be involved in emotion regulation and processing. Nonetheless, the complex and heterogeneous nature of BD has not yet allowed the identification of a clear biological signature of this disorder.Purpose of ReviewIn this context, this review aims to a) briefly summarize the evidence from structural Magnetic Resonance Imaging (MRI) studies on BD in order to provide a clearer picture of the neural circuits involved in this disabling mental illness, and b) describe some critical clinical issues that need to be taken into account when studying BD, especially the history of psychosis and the link between BD and behavioral variant fronto-temporal dementia (bvFTD).SummaryEvidence from structural MRI studies on BD suggests ventricular, prefrontal and temporal abnormalities but remain largely inconsistent, possibly reflecting the disorder complexity. Moreover, the reviewed evidence showed that psychotic BD might represent a subtype of the disorder with specific and enhanced alterations of GM morphology. Finally, from the available MRI evidence exploring the relationship between BD and bvFTD emerged the need of a differential identification of biolog...
Source: Current Behavioral Neuroscience Reports - Category: Neuroscience Source Type: research

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Authors: Jones MT, Strassnig MT, Harvey PD Abstract INTRODUCTION: While antipsychotics have been generally successful in treating psychosis in schizophrenia, there is a major treatment gap for negative symptoms and cognitive deficits. Given that these aspects of the disease contribute to poor functional outcomes independently of positive symptoms, treatments would have profound implications for quality of life. The 5-HT2A- receptor has been considered a potential target for interventions aimed at negative and cognitive symptoms and multiple antagonists and inverse agonists of this receptor have been tested. ARE...
Source: Expert Opinion on Emerging Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Emerg Drugs Source Type: research
Do you have difficult — or even toxic — family members? How does one go about setting boundaries with them? And is it OK to cut them off? In today’s Not Crazy podcast, Jackie and Gabe tackle these tough questions with Sonya Mastick, a mental health advocate and fellow podcaster of a show called “What Won’t She Say?” Sonya shares her personal story of how she handled her toxic mom and demonstrates how it’s OK, and sometimes even necessary, to set strong boundaries with family members who hurt you. It’s also OK if those boundaries shift and evolve with time. Tune in for an hon...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Family General Interview LifeHelper Mental Health and Wellness Not Crazy Podcast Source Type: blogs
CONCLUSIONS: We were able to achieve a high accuracy for machine learning technique in distinguishing BD from HV using a combination of multimodal neuroimaging and neurocognitive measures. Findings of this proof of concept study, if replicated in larger samples, could have potential clinical applications. PMID: 32143176 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Conclusions: PLWH with mood disorders were at increased risk of incident NCDs and multimorbidity, particularly metabolic syndrome. Focused prevention and treatment of NCDs may reduce the burden of multimorbidity in this high-risk group.
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - Category: Infectious Diseases Tags: Clinical Science Source Type: research
This article summarizes the milestones in the development of lumateperone leading to this first approval for the treatment of schizophrenia.
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
This study aimed to investigate the association between anticholinergic medications and the risk of dementia using data from Taiwan's National Health Research Database (NHIRD).MethodsA total of 790,240 patients, with 197,560 patients receiving anticholinergic medications and 592,680 control patients (1:3) matched for sex, age, and index-year, were enrolled from the two million Longitudinal Health Insurance Dataset, a subdataset of the NHIRD, between 2000 and 2015. The time-dependent Cox regression analysis was used to explore the hazard ratio (HR) with a 95% confidence interval for the association between anticholinergics ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 1 February 2020Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Gabriel R. Fries, Madeline J. Zamzow, Taylor Andrews, Omar Pink, Giselli Scaini, Joao QuevedoAbstractBipolar disorder (BD) has been associated with clinical signs of accelerated aging, which potentially underlies its association with several age-related medical conditions, such as hypertension, metabolic imbalances, dementia, and cancer. This paper aims to comprehensively review evidence of biological aging in BD and explore findings and controversies related to common biological clocks in patients, including telomer...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
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Source: Journal of Neurodevelopmental Disorders - Category: Neurology Source Type: research
Most people know that drinking alcohol to excess isn’t good for you, but does it mean you are an alcoholic? People who drink sometimes test limits and boundaries which could lead to binge drinking, whether intentional or unintentional. How can you tell if you’ve crossed the line between binge drinking and alcohol use disorder, and the answer to “is a binge drinker an alcoholic”? What Technically Is a Binge Drinker? The National Institute on Alcohol Abuse and Alcoholism defines binge drinking as a pattern of drinking that brings blood alcohol concentration (BAC) levels to 0.08 g/dL. This typically o...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Recovery Alcohol Rehab Information Alcoholism alcohol abuse alcohol detox alcohol treatment alcohol treatment center alcohol treatment facility binge binge drinking Source Type: blogs
Conclusion: In daily care practice the relationship between well-being and psychiatric and behavioral problems should be taken into account in care planning and treatment. To further explore the direction and details of this relationship, more research is needed. PMID: 31847540 [PubMed - as supplied by publisher]
Source: Aging and Mental Health - Category: Geriatrics Authors: Tags: Aging Ment Health Source Type: research
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