Effects of location, climate, soil conditions and plant species on levels of potentially toxic elements in Chinese Prickly Ash pericarps from the main cultivation regions in China.
This study reports levels of aluminium (Al), arsenic (As), cadmium (Cd), lead (Pb), manganese (Mn) and nickel (Ni) in the soils where Chinese Prickly Ash - Zanthoxylum bungeanum (ZB) and Z. armatum (ZA) are grown. Soil and pericarp samples were taken from 72 ZB and ZA plantations in 12 provinces. The soil pollution index (PI) was generally low for As (0.04-0.35), Pb (0.01-0.74) and Ni (0.15-1.06). The PI was higher for Cd (0.06-6.99) and was assessed at three categorical levels: 'low' (in 26% of soils), 'moderate' (in 67% of soils) and high (in 7% of soils). The majority (94%) of soils were slightly polluted with Cd with the integrated pollution index in the range 0.17-2.02. More than 60% of pericarp samples posed a high non-cancer health risk based on the hazard index, while 43% of pericarp samples posed a considerable cancer risk based on the incremental lifetime cancer risk. The mean temperature and the mean relative humidity contributed most significantly (28% and 10%, respectively) to variation in the concentrations of potentially toxic elements in the pericarps. This study provides a comprehensive report on the concentrations of potentially toxic elements in the soils and associated pericarps, and the effects of location, climate, and soil on the levels of potentially toxic elements in the soil and pericarps, including the effects of tree species. PMID: 31812048 [PubMed - indexed for MEDLINE]
ConclusionsUnlike [18F]FDG, [18F]BODIPY 1 showed prominent accumulation in BAT under both inactive and stimulated status. [18F]BODIPY 1 may serve as a valuable BAT PET agent to possibly assess BAT mitochondria density, thus BAT thermogenic capacity after further evaluation.
ConclusionsHypoxia modulation may play a role in nal-IRI ’s mechanism of action. Nal-IRI demonstrated greater anti-tumor activity in the more aggressive and hypoxic tumor model. Furthermore, hypoxia imaging provided early prediction of treatment response.
AbstractPurposeTo investigate and validate the potential role of a radiomics signature in predicting the side-specific probability of extracapsular extension (ECE) of prostate cancer (PCa).ProceduresThe preoperative magnetic resonance imaging data of 238 prostatic samples from 119 enrolled PCa patients were retrospectively assessed. The samples with were randomized in a two-to-one ratio into training (n = 74) and validation (n = 45) datasets. The radiomics features were derived from T2-weighted images (T2WIs). The optimal radiomics features were identified from the least absolute shrinkage and s...
ConclusionsIntegrated [68Ga]PSMA-11 PET/MRI provides a similarly high diagnostic performance for localization of recurrent PC as PET/CT. For the detection of local recurrences [68Ga]PSMA-11 PET/MRI is superior compared with [68Ga]PSMA-11 PET/CT.
Publication date: Available online 25 May 2020Source: Life SciencesAuthor(s): Serena L'Abbate, Ilaria Russo, Claudia Kusmic
Dear colleagues, please advise concerning this patient: 40 yo male, high PS, diagnosed a couple of years ago of colic cancer that was locally treated. Aug 2020: he was diagnosed of left parietal (at the level of the motor strip) solitary brain lesion. octobre 2020: he underwent a complete resection , followed by cavity SRS 18Gy /1 fr April 2020: refractory seizures MRI showed a relapsing left parietal cavity lesion, whose epicenter was next to the trolard vein. he was re-resected quasi... re-irradiation after single fraction cavity SRS? What dose?
Publication date: Available online 12 May 2020Source: The Journal of Molecular DiagnosticsAuthor(s): Manny D. Bacolod, Aashiq H. Mirza, Jianmin Huang, Sarah F. Giardina, Philip B. Feinberg, Steven A. Soper, Francis Barany
To observe the surgical index at the different learning stages of thoraco-laparoscopic esophagectomy in the prone position for esophageal cancer and to investigate the learning curve of this surgical procedure.
We report that the loss of 4.1N correlated with progress in clinical stage, as well as poor survival in EOC patients. The loss of 4.1N induces EMT in adherent EOC cells and its expression inhibits anoikis resistance and EMT by directly binding and accelerating the degradation of 14-3-3 in suspension EOC cells. Furthermore, the loss of 4.1N could increase the rate of entosis, which aggravates cell death resistance in suspension EOC cells. Moreover, xenograft tumors in nude mice also show that the loss of 4.1N can aggravate peritoneal dissemination of EOC cells. Single-agent and combination therapy with a ROCK inhibitor and ...
Publication date: Available online 26 May 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Radosław Mlak, Tomasz Powrózek, Anna Brzozowska, Iwona Homa-Mlak, Marcin Mazurek, Paweł Gołębiowski, Dorota Korzeb, Mansur Rahnama-Hezavah, Teresa Małecka-Massalska