Analgesic Effect of Intraoperative Intravenous S-Ketamine in Opioid-Na ïve Patients After Major Lumbar Fusion Surgery Is Temporary and Not Dose-Dependent: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

CONCLUSIONS: Neither a 0.12 nor a 0.6 mg/kg/h infusion of intraoperative IV S-ketamine was superior to the placebo in reducing oxycodone consumption at 48 hours after lumbar fusion surgery in an opioid-naïve adult study population. Future studies should assess ketamine's feasibility in specific study populations who most benefit from reduced opioid consumption. PMID: 32167978 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32167978?dopt=Abstract

Source: Anesthesia and Analgesia - March 8, 2020 Category: Anesthesiology Authors: Brinck ECV, Maisniemi K, Kankare J, Tielinen L, Tarkkila P, Kontinen VK Tags: Anesth Analg Source Type: research