Successful Treatment of Paraneoplastic Cholestasis in Relapsed/Refractory Hodgkin Lymphoma With Bridging Therapy and Checkpoint Blockade

Paraneoplastic cholestasis (PC) is a rare manifestation of Hodgkin lymphoma (HL). It is comprised of 2 distinct pathologic entities: vanishing bile duct syndrome (VBDS) and idiopathic cholestasis (IC) without ductopenia. There are less than 20 published cases of IC in HL, with none reported in relapsed HL. Treatment of PC is challenging as many chemotherapeutic agents are metabolized by the liver. There is no literature available regarding the treatment of IC in relapsed HL. Here, we present the first report of successful treatment of a patient with IC in the setting of relapsed HL post autologous stem cell support (ASCT) with bridging therapy (cyclophosphamide, methylprednisolone) and sequential nivolumab.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research