Zika combats advanced-stage central nervous system tumors in dogs

(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) The viral therapy was tested in three elderly animals with spontaneous brain tumors by a group affiliated with the FAPESP-funded Human Genome and Stem Cell Research Center.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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The ability of self-replicating oncolytic viruses (OVs) to preferentially infect and lyse cancer cells while stimulating anti-tumor immunity of the host strongly indicates its value as a new field of cancer therapeutics to be further explored. The emergence of Zika virus (ZIKV) as a global health threat due to its recent outbreak in Brazil has caught the attention of the scientific community and led to the discovery of its oncolytic potential for the treatment of glioblastoma multiforme (GBM), the most common and fatal brain tumor with poor prognosis. Herein, we evaluate the neurotropism of ZIKV relative to the receptor ty...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
TUESDAY, Sept. 18, 2018 -- Preliminary research in mice suggests that the Zika virus might be turned from foe into friend -- enlisted to curb deadly glioblastoma brain tumors. A glioblastoma is among the most lethal of brain cancers, killing more...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
The same virus that causes devastating birth defects to children's brains shrunk brain tumors that usually strike under-fives in 70 percent of mice in a groundbreaking new Brazilian study.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
(University of Sao Paulo Scientific Outreach Unit) Brazilian researchers at the Center for Human Genome and Stem Cell Studies at the University of S ã o Paulo have put the virus to good use showing, for the first time in animals, the deleterious effect of the injection of a low concentration of the purified virus on human embryonic brain tumors induced in mice with low immunity.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) Study by Brazilian researchers shows infection by Zika caused death of cells from glioblastoma, the most common and aggressive kind of malignant brain tumor in adults. Scientists foresee the use of genetic engineering to neutralize Zika virus' infectious whilst preserving the viral particles which induce the death of tumoral cells.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
This study brings light to unexpectedly induced metabolic changes, as endogenous digoxin as important biomarker for ZIKV‐GBM group, associated with cytopathic effects induced by viral infection. These result evidences that genetically engineered ZIKV might be a potential new strategy for neural cancer management through the induction of endogenous digoxin synthesis in GBM cells.
Source: Journal of Mass Spectrometry - Category: Chemistry Authors: Tags: ACCELERATED COMMUNICATION Source Type: research
This study brings light to unexpectedly induced metabolic changes, as endogenous Digoxin as important biomarker for ZIKV‐GBM group, associated with cytopathic effects induced by viral infection. These results evidences that genetically engineered ZIKV might be a potential new strategy for neural cancer management through the induction of endogenous digoxin synthesis in glioblastoma cells.
Source: Journal of Mass Spectrometry - Category: Chemistry Authors: Tags: ACCELERATED COMMUNICATION Source Type: research
Not long ago, Zika virus was dominating headlines. A new infection was hardly ever heard about before then, yet is now affecting hundreds of thousands of people in Latin America, causing disfiguration and microcephalia in new-born babies. Microcephalia is caused by severe delayed and abnormal development of the brain, resulting in the range of intellectual disability, dwarfism, poor motor functions and speech. With no cure or even preventive vaccination available, many women in the most affected regions were reportedly considering postponing any planned pregnancies. The virus was actually discovered back in 1947 in Zika fo...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior Brain Blogger Health-related Publishers Research brain cancer Delivery glioblastoma Immune System microcephalia Pregnancy Sexual Contact stem cells Zika virus Source Type: blogs
Conclusion This is an interesting piece of research that shows how knowledge in one field of medicine can sometimes be applied to another field with surprising results. But it's important to be realistic about the stage of research. This is very much a "proof of concept" study, and tests on cells, tissues and mice don't necessarily translate into a safe and effective treatment for humans. The study has several limitations, but the fact the treatment so far hasn't been tested on humans is the most important. For one thing, Zika virus doesn't naturally infect mice, so researchers had to use a specially engineered v...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Source Type: news
Zika's most damaging quality could be weaponized against brain tumor cells.
Source: Science - The Huffington Post - Category: Science Source Type: news
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