Protective effects of luteolin against oxidative stress and mitochondrial dysfunction in endothelial cells

Luteolin is a common flavonoid that is abundantly present in various edible plants, it is known to exhibit beneficial effects on cardiovascular system. However, the mechanisms which underlie the protective effects of luteolin on endothelial cell damage caused by oxidative stress remains unclear. The purpose of this study is to test the hypothesis which states that luteolin protects against H2O2-induced oxidative stress via modulating ROS-mediated P38 MAPK/NF- κB and calcium-evoked mitochondrial apoptotic signalling pathways.

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 8, 2020 Category: Nutrition Authors: Hsiu-I. Chen, Weii-Syuun Hu, Meng-Yu Hung, Hsiu-Chung Ou, Su-Hua Huang, Pei-Tzu Hsu, Cecilia-Hsuan Day, Kuan-Ho Lin, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang Source Type: research