Myocardial Energetics in Obesity: Enhanced ATP Delivery Through Creatine Kinase with Blunted Stress Response.

Conclusions: In the obese resting heart, the myocardial CK reaction rate is increased, maintaining ATP delivery despite reduced PCr/ATP. During increased workload, whilst the non-obese heart increases ATP delivery through CK, the obese heart does not; this is associated with reduced systolic augmentation and exercise tolerance. Weight loss reverses these energetic changes. This highlights myocardial energy delivery via CK as a potential therapeutic target to improve symptoms in obesity-related heart disease, as well as a fascinating modifiable pathway involved in the progression to heart failure.
PMID: 32138541 [PubMed - as supplied by publisher]

Source: Circulation - March 5, 2020 Category: Cardiology Authors: Rayner JJ, Peterzan MA, Watson WD, Clarke WT, Neubauer S, Rodgers CT, Rider OJ Tags: Circulation Source Type: research